Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Salsalate
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate, a salicylate NSAID, can diminish the blood pressure lowering effect of valsartan and hydrochlorothiazide. Combined with an ARB and a diuretic it raises the risk of acute kidney injury, especially in elderly or volume-depleted patients, and may contribute to hyperkalemia.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Reduced synthesis of vasodilatory renal prostaglandins lowers glomerular perfusion and counteracts antihypertensive and natriuretic effects.
What to do
Monitor blood pressure, renal function and potassium within the first weeks of combined use and maintain hydration. Use the lowest effective salsalate dose for the shortest time, or choose an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Salsalate?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate, a salicylate NSAID, can diminish the blood pressure lowering effect of valsartan and hydrochlorothiazide. Combined with an ARB and a diuretic it raises the risk of acute kidney injury, especially in elderly or volume-depleted patients, and may contribute to hyperkalemia.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium within the first weeks of combined use and maintain hydration. Use the lowest effective salsalate dose for the shortest time, or choose an alternative analgesic.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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