Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Sodium sulfate / ?magnesium sulfate / potassium chloride
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Sodium sulfate / ?magnesium sulfate / potassium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osmotic bowel preparations cause fluid loss and electrolyte shifts. With a thiazide diuretic and an ARB this increases the risk of dehydration, hypotension, arrhythmia and acute kidney injury. Magnesium may add to calcium channel blocker effects.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive volume depletion and electrolyte disturbance from the bowel preparation and the diuretic, with ARB-impaired renal autoregulation.
What to do
Ensure adequate hydration and consider withholding the diuretic and ARB on the day of bowel preparation. Check electrolytes and renal function in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-hydrochlorothiazide-valsartan and Sodium sulfate / ?magnesium sulfate / potassium chloride, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osmotic bowel preparations cause fluid loss and electrolyte shifts. With a thiazide diuretic and an ARB this increases the risk of dehydration, hypotension, arrhythmia and acute kidney injury. Magnesium may add to calcium channel blocker effects.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and consider withholding the diuretic and ARB on the day of bowel preparation. Check electrolytes and renal function in high-risk patients.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
