Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Sodium sulfate / potassium sulfate / magnesium sulfate
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Sodium sulfate / potassium sulfate / magnesium sulfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfate-based bowel preparations cause fluid and electrolyte loss, which together with a thiazide and an ARB raises the risk of dehydration, hypotension and kidney injury. Absorbed magnesium may add to calcium channel blocker effects.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Sodium sulfate / potassium sulfate / magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive volume depletion and electrolyte disturbance with ARB-impaired renal autoregulation.
What to do
Encourage adequate fluid intake and consider holding the diuretic and ARB on preparation day. Monitor electrolytes and creatinine in elderly or renally impaired patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Sodium sulfate / potassium sulfate / magnesium sulfate?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Sodium sulfate / potassium sulfate / magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfate-based bowel preparations cause fluid and electrolyte loss, which together with a thiazide and an ARB raises the risk of dehydration, hypotension and kidney injury. Absorbed magnesium may add to calcium channel blocker effects.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Sodium sulfate / potassium sulfate / magnesium sulfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Encourage adequate fluid intake and consider holding the diuretic and ARB on preparation day. Monitor electrolytes and creatinine in elderly or renally impaired patients.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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