Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Sofosbuvir / velpatasvir
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Sofosbuvir / velpatasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir inhibits OATP1B1/1B3 transporters, which may increase valsartan exposure. The effect is expected to be modest and may result in increased hypotension.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Sofosbuvir / velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of hepatic OATP uptake of valsartan by velpatasvir.
What to do
Monitor blood pressure during hepatitis C treatment and adjust antihypertensive dosing if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Sofosbuvir / velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Velpatasvir inhibits OATP1B1/1B3 transporters, which may increase valsartan exposure. The effect is expected to be modest and may result in increased hypotension.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Sofosbuvir / velpatasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during hepatitis C treatment and adjust antihypertensive dosing if hypotension occurs.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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