Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Sulfasalazine
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Sulfasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine has limited NSAID-like prostaglandin effects, and a clinically important reduction in antihypertensive effect is not well established. Its salicylate component is minimally active against renal prostaglandins, so interaction is likely small.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak prostaglandin inhibition; not firmly established for sulfasalazine.
What to do
No routine action is needed; check blood pressure and renal function if the patient is volume-depleted or has renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Sulfasalazine?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfasalazine has limited NSAID-like prostaglandin effects, and a clinically important reduction in antihypertensive effect is not well established. Its salicylate component is minimally active against renal prostaglandins, so interaction is likely small.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Sulfasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; check blood pressure and renal function if the patient is volume-depleted or has renal impairment.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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