Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Synthetic human angiotensin ii
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Synthetic human angiotensin ii: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan blocks AT1 receptors and so opposes the pressor action of exogenous angiotensin II. Patients on ARBs may need higher angiotensin II doses to treat vasodilatory shock.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism at the AT1 receptor.
What to do
Titrate angiotensin II to blood pressure response, expecting higher dose requirements in patients on ARBs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Synthetic human angiotensin ii?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valsartan blocks AT1 receptors and so opposes the pressor action of exogenous angiotensin II. Patients on ARBs may need higher angiotensin II doses to treat vasodilatory shock.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Synthetic human angiotensin ii?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate angiotensin II to blood pressure response, expecting higher dose requirements in patients on ARBs.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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