Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Trilostane
Severity: Major
Amlodipine-hydrochlorothiazide-valsartan and Trilostane: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trilostane inhibits adrenal steroid synthesis, reducing aldosterone and promoting potassium retention. With valsartan this raises hyperkalemia risk, and hypotension may also be enhanced.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Trilostane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of adrenal steroidogenesis lowers aldosterone, adding to angiotensin receptor blockade effects on potassium and blood pressure.
What to do
Monitor serum potassium and blood pressure closely, and avoid potassium supplements. Adjust therapy if hyperkalemia or hypotension occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Trilostane?
MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Trilostane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trilostane inhibits adrenal steroid synthesis, reducing aldosterone and promoting potassium retention. With valsartan this raises hyperkalemia risk, and hypotension may also be enhanced.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Trilostane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure closely, and avoid potassium supplements. Adjust therapy if hyperkalemia or hypotension occurs.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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