Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Umeclidinium bromide / vilanterol inhaled
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Umeclidinium bromide / vilanterol inhaled: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a beta-agonist, can lower serum potassium, and this adds to thiazide-induced hypokalemia. This may provoke ECG changes or arrhythmias, mainly with excess dosing or other risk factors.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Umeclidinium bromide / vilanterol inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Beta-2 stimulation shifts potassium into cells, adding to renal potassium loss from hydrochlorothiazide.
What to do
Monitor serum potassium in patients with risk factors such as heart disease or high doses. Replace potassium or adjust therapy if hypokalemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Umeclidinium bromide / vilanterol inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vilanterol, a beta-agonist, can lower serum potassium, and this adds to thiazide-induced hypokalemia. This may provoke ECG changes or arrhythmias, mainly with excess dosing or other risk factors.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients with risk factors such as heart disease or high doses. Replace potassium or adjust therapy if hypokalemia occurs.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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