Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Xipamide
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Xipamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Xipamide is a thiazide-like diuretic, so combining it with hydrochlorothiazide duplicates diuretic therapy. This increases the risk of volume depletion, hypotension, hypokalemia, hyponatremia and renal impairment, especially with valsartan.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Duplicate thiazide-type diuretic action causing additive natriuresis and electrolyte loss.
What to do
Avoid concurrent use of two thiazide-type diuretics where possible; if combined, monitor electrolytes, renal function and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Xipamide?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Xipamide is a thiazide-like diuretic, so combining it with hydrochlorothiazide duplicates diuretic therapy. This increases the risk of volume depletion, hypotension, hypokalemia, hyponatremia and renal impairment, especially with valsartan.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Xipamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two thiazide-type diuretics where possible; if combined, monitor electrolytes, renal function and blood pressure.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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