Drug interactions
Amlodipine-olmesartan + Bosentan
Severity: Moderate
Amlodipine-olmesartan and Bosentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan is a moderate CYP3A4 inducer and may lower amlodipine concentrations, reducing blood pressure control. Bosentan itself can also cause hypotension, so the net effect varies between patients.
What this interaction means in plain words
Amlodipine-olmesartan and Bosentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Bosentan belongs to Miscellaneous.
Why it happens
Induction of CYP3A4 by bosentan increases amlodipine metabolism, plus additive pharmacodynamic hypotension.
What to do
Monitor blood pressure after starting, adjusting or stopping bosentan and titrate amlodipine accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Bosentan?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Bosentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan is a moderate CYP3A4 inducer and may lower amlodipine concentrations, reducing blood pressure control. Bosentan itself can also cause hypotension, so the net effect varies between patients.
How serious is the interaction between Amlodipine-olmesartan and Bosentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting, adjusting or stopping bosentan and titrate amlodipine accordingly.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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