Drug interactions
Bosentan + Lonafarnib
Severity: Contraindicated
Bosentan and Lonafarnib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A4 substrate, and bosentan as a moderate inducer may substantially reduce its exposure and effectiveness. Lonafarnib labeling contraindicates moderate and strong CYP3A inducers.
What this interaction means in plain words
Bosentan and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Bosentan belongs to Miscellaneous; Lonafarnib belongs to Miscellaneous.
Why it happens
CYP3A4 induction by bosentan increases lonafarnib clearance.
What to do
Do not coadminister; use an alternative to bosentan.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Cyclosporine Contraindicated
- Bosentan + Glyburide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
- Crizotinib + Lonafarnib Contraindicated
Frequently asked questions
Can I take Bosentan with Lonafarnib?
MediHelp rates the interaction as contraindicated. Bosentan and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lonafarnib is a sensitive CYP3A4 substrate, and bosentan as a moderate inducer may substantially reduce its exposure and effectiveness. Lonafarnib labeling contraindicates moderate and strong CYP3A inducers.
How serious is the interaction between Bosentan and Lonafarnib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative to bosentan.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Cyclosporine, Glyburide. The full list is on the Bosentan page.
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