Drug interactions
Amlodipine-olmesartan + Chloramphenicol
Severity: Minor
Amlodipine-olmesartan and Chloramphenicol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol inhibits CYP3A4 to some extent and could raise amlodipine concentrations, causing more hypotension and peripheral edema. The effect is predicted rather than well documented for amlodipine.
What this interaction means in plain words
Amlodipine-olmesartan and Chloramphenicol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-olmesartan belongs to Cardiovascular; Chloramphenicol belongs to Anti Bacterial.
Why it happens
Possible inhibition of CYP3A4-mediated amlodipine metabolism.
What to do
Monitor blood pressure and for edema or dizziness during chloramphenicol therapy, and reduce the amlodipine dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Chloramphenicol
Frequently asked questions
Can I take Amlodipine-olmesartan with Chloramphenicol?
MediHelp rates the interaction as minor. Amlodipine-olmesartan and Chloramphenicol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chloramphenicol inhibits CYP3A4 to some extent and could raise amlodipine concentrations, causing more hypotension and peripheral edema. The effect is predicted rather than well documented for amlodipine.
How serious is the interaction between Amlodipine-olmesartan and Chloramphenicol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for edema or dizziness during chloramphenicol therapy, and reduce the amlodipine dose if hypotension occurs.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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