Drug interactions
Amlodipine-olmesartan + Chlorothiazide
Severity: Minor
Amlodipine-olmesartan and Chlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
An ARB combined with a thiazide diuretic is a standard antihypertensive pairing with additive effect. Potassium loss from the thiazide is partly offset by olmesartan. Hypotension, volume depletion and electrolyte shifts can occur, especially early in treatment.
What this interaction means in plain words
Amlodipine-olmesartan and Chlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-olmesartan belongs to Cardiovascular; Chlorothiazide belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering, with thiazide kaliuresis opposed by ARB-induced aldosterone suppression.
What to do
Check blood pressure, serum potassium, sodium and renal function after starting or adjusting therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Amlodipine-olmesartan with Chlorothiazide?
MediHelp rates the interaction as minor. Amlodipine-olmesartan and Chlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. An ARB combined with a thiazide diuretic is a standard antihypertensive pairing with additive effect. Potassium loss from the thiazide is partly offset by olmesartan. Hypotension, volume depletion and electrolyte shifts can occur, especially early in treatment.
How serious is the interaction between Amlodipine-olmesartan and Chlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure, serum potassium, sodium and renal function after starting or adjusting therapy.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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