Drug interactions
Amlodipine-olmesartan + Diflunisal
Severity: Moderate
Amlodipine-olmesartan and Diflunisal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diflunisal can blunt the blood pressure lowering effect of olmesartan. In combination with an angiotensin receptor blocker, NSAIDs can also reduce glomerular filtration and cause acute kidney injury, especially in elderly or volume-depleted patients, and may raise serum potassium.
What this interaction means in plain words
Amlodipine-olmesartan and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Diflunisal belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal perfusion and sodium excretion, opposing ARB effects and impairing glomerular filtration.
What to do
Monitor blood pressure, serum creatinine and potassium when starting or stopping diflunisal, and ensure adequate hydration. Use the lowest effective NSAID dose for the shortest time, or choose an alternative analgesic such as paracetamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Diflunisal?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diflunisal can blunt the blood pressure lowering effect of olmesartan. In combination with an angiotensin receptor blocker, NSAIDs can also reduce glomerular filtration and cause acute kidney injury, especially in elderly or volume-depleted patients, and may raise serum potassium.
How serious is the interaction between Amlodipine-olmesartan and Diflunisal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium when starting or stopping diflunisal, and ensure adequate hydration. Use the lowest effective NSAID dose for the shortest time, or choose an alternative analgesic such as paracetamol.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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