Drug interactions
Amlodipine-olmesartan + Isavuconazonium
Severity: Moderate
Amlodipine-olmesartan and Isavuconazonium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a CYP3A4 substrate and moderate inhibitor, so it is amlodipine that is expected to be affected, with higher amlodipine levels causing hypotension and edema. Amlodipine is a weak CYP3A4 inhibitor and is unlikely to change isavuconazole exposure meaningfully.
What this interaction means in plain words
Amlodipine-olmesartan and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Isavuconazonium belongs to Anti Fungals.
Why it happens
Isavuconazole inhibition of CYP3A4 reduces amlodipine metabolism.
What to do
Monitor blood pressure and peripheral edema, and reduce the amlodipine dose if adverse effects appear during isavuconazole therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan with Isavuconazonium?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole is a CYP3A4 substrate and moderate inhibitor, so it is amlodipine that is expected to be affected, with higher amlodipine levels causing hypotension and edema. Amlodipine is a weak CYP3A4 inhibitor and is unlikely to change isavuconazole exposure meaningfully.
How serious is the interaction between Amlodipine-olmesartan and Isavuconazonium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and peripheral edema, and reduce the amlodipine dose if adverse effects appear during isavuconazole therapy.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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