Drug interactions
Amobarbital + Isavuconazonium
Severity: Contraindicated
Amobarbital and Isavuconazonium: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inducers of CYP3A4 such as barbiturates lower isavuconazole concentrations considerably. Subtherapeutic exposure risks failure of treatment of serious invasive fungal infection. Strong inducers are contraindicated in the labeling.
What this interaction means in plain words
Amobarbital and Isavuconazonium are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amobarbital belongs to Central Nervous System; Isavuconazonium belongs to Anti Fungals.
Why it happens
Barbiturate-mediated CYP3A4 induction increases isavuconazole clearance.
What to do
Avoid the combination and choose a non-inducing sedative. If an inducer is essential, consider a different antifungal.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Amobarbital + Lorlatinib Contraindicated
Other interactions of Isavuconazonium
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Isavuconazonium + Ketoconazole Contraindicated
Frequently asked questions
Can I take Amobarbital with Isavuconazonium?
MediHelp rates the interaction as contraindicated. Amobarbital and Isavuconazonium are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Inducers of CYP3A4 such as barbiturates lower isavuconazole concentrations considerably. Subtherapeutic exposure risks failure of treatment of serious invasive fungal infection. Strong inducers are contraindicated in the labeling.
How serious is the interaction between Amobarbital and Isavuconazonium?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-inducing sedative. If an inducer is essential, consider a different antifungal.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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