Drug interactions
Amlodipine-olmesartan + Lemborexant
Severity: Moderate
Amlodipine-olmesartan and Lemborexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine is a weak CYP3A4 inhibitor and can increase lemborexant exposure, raising the risk of next-day somnolence and impaired alertness.
What this interaction means in plain words
Amlodipine-olmesartan and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Lemborexant belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated metabolism of lemborexant by amlodipine.
What to do
Limit lemborexant to the lower recommended nightly dose with weak CYP3A4 inhibitors and monitor for daytime sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-olmesartan and Lemborexant, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Lemborexant
Frequently asked questions
Can I take Amlodipine-olmesartan with Lemborexant?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine is a weak CYP3A4 inhibitor and can increase lemborexant exposure, raising the risk of next-day somnolence and impaired alertness.
How serious is the interaction between Amlodipine-olmesartan and Lemborexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit lemborexant to the lower recommended nightly dose with weak CYP3A4 inhibitors and monitor for daytime sedation.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
