Drug interactions
Chloramphenicol + Lemborexant
Severity: Major
Chloramphenicol and Lemborexant: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lemborexant is metabolized mainly by CYP3A4, and inhibitors increase its exposure. This may cause excessive somnolence, next-day impairment and complex sleep behaviors.
What this interaction means in plain words
Chloramphenicol and Lemborexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Lemborexant belongs to Central Nervous System.
Why it happens
Chloramphenicol inhibits CYP3A4, reducing lemborexant clearance.
What to do
Avoid the combination and consider another hypnotic or antibiotic. If lemborexant must continue, use the lowest dose and monitor for daytime sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chloramphenicol and Lemborexant, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Chloramphenicol
Other interactions of Lemborexant
Frequently asked questions
Can I take Chloramphenicol with Lemborexant?
MediHelp rates the interaction as major. Chloramphenicol and Lemborexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lemborexant is metabolized mainly by CYP3A4, and inhibitors increase its exposure. This may cause excessive somnolence, next-day impairment and complex sleep behaviors.
How serious is the interaction between Chloramphenicol and Lemborexant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and consider another hypnotic or antibiotic. If lemborexant must continue, use the lowest dose and monitor for daytime sedation.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
