Drug interactions
Amiodarone + Lemborexant
Severity: Major
Amiodarone and Lemborexant: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone can raise lemborexant exposure through CYP3A4 inhibition. Higher levels may cause excessive sedation, next-day somnolence and impaired psychomotor performance.
What this interaction means in plain words
Amiodarone and Lemborexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Lemborexant belongs to Central Nervous System.
Why it happens
Amiodarone inhibits CYP3A4, reducing the metabolic clearance of lemborexant.
What to do
Avoid the combination where possible; if used, keep lemborexant at the lowest recommended dose per labeling for CYP3A inhibitors and monitor for daytime sedation. Consider an alternative hypnotic not dependent on CYP3A4.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amiodarone and Lemborexant, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Amiodarone with Lemborexant?
MediHelp rates the interaction as major. Amiodarone and Lemborexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone can raise lemborexant exposure through CYP3A4 inhibition. Higher levels may cause excessive sedation, next-day somnolence and impaired psychomotor performance.
How serious is the interaction between Amiodarone and Lemborexant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, keep lemborexant at the lowest recommended dose per labeling for CYP3A inhibitors and monitor for daytime sedation. Consider an alternative hypnotic not dependent on CYP3A4.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
