Drug interactions
Amlodipine-olmesartan + Leniolisib
Severity: Moderate
Amlodipine-olmesartan and Leniolisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits hepatic OATP1B1 and OATP1B3 uptake transporters, which can raise systemic exposure to olmesartan. Higher olmesartan levels may enhance blood pressure lowering, hyperkalemia and renal effects.
What this interaction means in plain words
Amlodipine-olmesartan and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Leniolisib belongs to Miscellaneous.
Why it happens
Inhibition of OATP1B1/1B3-mediated hepatic uptake of olmesartan reduces its clearance.
What to do
Monitor blood pressure, serum potassium and renal function when starting leniolisib. Reduce the olmesartan dose if hypotension or other adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Leniolisib
Frequently asked questions
Can I take Amlodipine-olmesartan with Leniolisib?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib inhibits hepatic OATP1B1 and OATP1B3 uptake transporters, which can raise systemic exposure to olmesartan. Higher olmesartan levels may enhance blood pressure lowering, hyperkalemia and renal effects.
How serious is the interaction between Amlodipine-olmesartan and Leniolisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium and renal function when starting leniolisib. Reduce the olmesartan dose if hypotension or other adverse effects develop.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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