Drug interactions
Apalutamide + Leniolisib
Severity: Major
Apalutamide and Leniolisib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may substantially lower leniolisib exposure since leniolisib is cleared mainly by CYP3A4. Reduced exposure could compromise control of activated PI3K delta syndrome.
What this interaction means in plain words
Apalutamide and Leniolisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Leniolisib belongs to Miscellaneous.
Why it happens
CYP3A4 induction by apalutamide increases leniolisib metabolism.
What to do
Avoid combining with strong CYP3A4 inducers as advised in leniolisib labeling. If unavoidable, monitor for loss of clinical effect.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Leniolisib
Frequently asked questions
Can I take Apalutamide with Leniolisib?
MediHelp rates the interaction as major. Apalutamide and Leniolisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide may substantially lower leniolisib exposure since leniolisib is cleared mainly by CYP3A4. Reduced exposure could compromise control of activated PI3K delta syndrome.
How serious is the interaction between Apalutamide and Leniolisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining with strong CYP3A4 inducers as advised in leniolisib labeling. If unavoidable, monitor for loss of clinical effect.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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