Drug interactions
Amlodipine-olmesartan + Mifepristone
Severity: Moderate
Amlodipine-olmesartan and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may increase amlodipine exposure, causing hypotension or edema. Effects are likely greatest with prolonged high-dose use, as in Cushing syndrome.
What this interaction means in plain words
Amlodipine-olmesartan and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Mifepristone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated amlodipine metabolism by mifepristone.
What to do
Monitor blood pressure and peripheral edema and reduce the amlodipine dose if excessive effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan with Mifepristone?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and may increase amlodipine exposure, causing hypotension or edema. Effects are likely greatest with prolonged high-dose use, as in Cushing syndrome.
How serious is the interaction between Amlodipine-olmesartan and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and peripheral edema and reduce the amlodipine dose if excessive effects occur.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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