Drug interactions
Amlodipine-olmesartan + Nicardipine
Severity: Moderate
Amlodipine-olmesartan and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine and nicardipine are both dihydropyridine calcium channel blockers, so combining them duplicates therapy. This adds hypotension, peripheral edema, flushing and reflex tachycardia without clear benefit.
What this interaction means in plain words
Amlodipine-olmesartan and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Nicardipine belongs to Cardiovascular.
Why it happens
Duplicate L-type calcium channel blockade causing additive vasodilation.
What to do
Avoid concurrent long-term use of two dihydropyridines and use a single agent. If overlap is unavoidable, such as during a switch, monitor blood pressure and edema.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Nicardipine
Frequently asked questions
Can I take Amlodipine-olmesartan with Nicardipine?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine and nicardipine are both dihydropyridine calcium channel blockers, so combining them duplicates therapy. This adds hypotension, peripheral edema, flushing and reflex tachycardia without clear benefit.
How serious is the interaction between Amlodipine-olmesartan and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent long-term use of two dihydropyridines and use a single agent. If overlap is unavoidable, such as during a switch, monitor blood pressure and edema.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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