Drug interactions
Amlodipine-olmesartan + Tolfenamic acid
Severity: Moderate
Amlodipine-olmesartan and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Like other NSAIDs, tolfenamic acid can reduce the antihypertensive effect of olmesartan and increase the risk of renal impairment and hyperkalemia. Elderly and volume-depleted patients are most vulnerable.
What this interaction means in plain words
Amlodipine-olmesartan and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal perfusion and opposes ARB effects.
What to do
Use the lowest effective dose for the shortest duration and keep the patient hydrated. Monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Amlodipine-olmesartan with Tolfenamic acid?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Like other NSAIDs, tolfenamic acid can reduce the antihypertensive effect of olmesartan and increase the risk of renal impairment and hyperkalemia. Elderly and volume-depleted patients are most vulnerable.
How serious is the interaction between Amlodipine-olmesartan and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dose for the shortest duration and keep the patient hydrated. Monitor blood pressure, creatinine and potassium.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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