Drug interactions
Celecoxib + Tolfenamic acid
Severity: Major
Celecoxib and Tolfenamic acid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking two NSAIDs together adds to the risk of gastrointestinal ulceration and bleeding, renal injury and cardiovascular events without improving efficacy. This duplication is generally avoided.
What this interaction means in plain words
Celecoxib and Tolfenamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Celecoxib belongs to Musculoskeletal; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
Additive cyclooxygenase inhibition leads to combined gastrointestinal, renal and platelet toxicity.
What to do
Avoid concurrent use of two NSAIDs and use a single agent at the lowest effective dose. If analgesia is inadequate, add paracetamol or another non-NSAID class.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Celecoxib with Tolfenamic acid?
MediHelp rates the interaction as major. Celecoxib and Tolfenamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Taking two NSAIDs together adds to the risk of gastrointestinal ulceration and bleeding, renal injury and cardiovascular events without improving efficacy. This duplication is generally avoided.
How serious is the interaction between Celecoxib and Tolfenamic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two NSAIDs and use a single agent at the lowest effective dose. If analgesia is inadequate, add paracetamol or another non-NSAID class.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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