Drug interactions
Amlodipine-olmesartan + Treprostinil
Severity: Moderate
Amlodipine-olmesartan and Treprostinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Treprostinil is a potent vasodilator, and combining it with antihypertensives such as amlodipine and olmesartan may cause additive blood pressure lowering. Symptomatic hypotension is the main concern.
What this interaction means in plain words
Amlodipine-olmesartan and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Treprostinil belongs to Cardiovascular.
Why it happens
Additive vasodilatory and blood pressure lowering effects.
What to do
Monitor blood pressure, especially during treprostinil initiation and dose titration, and reduce antihypertensive doses if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Treprostinil
Frequently asked questions
Can I take Amlodipine-olmesartan with Treprostinil?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Treprostinil is a potent vasodilator, and combining it with antihypertensives such as amlodipine and olmesartan may cause additive blood pressure lowering. Symptomatic hypotension is the main concern.
How serious is the interaction between Amlodipine-olmesartan and Treprostinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, especially during treprostinil initiation and dose titration, and reduce antihypertensive doses if hypotension occurs.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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