Drug interactions
Amlodipine-olmesartan + Trofinetide
Severity: Moderate
Amlodipine-olmesartan and Trofinetide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trofinetide may inhibit OATP1B1 and OATP1B3 transporters, which could increase olmesartan concentrations. This may amplify hypotension, hyperkalemia or renal effects of olmesartan.
What this interaction means in plain words
Amlodipine-olmesartan and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Trofinetide belongs to Central Nervous System.
Why it happens
Predicted inhibition of OATP1B1/1B3-mediated hepatic uptake of olmesartan.
What to do
Monitor blood pressure, potassium and renal function when the two are combined. Lower the olmesartan dose if exaggerated effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-olmesartan and Trofinetide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Trofinetide
- Amlodipine-hydrochlorothiazide-valsartan + Trofinetide Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Trofinetide Moderate
- Amlodipine-valsartan + Trofinetide Moderate
- Atorvastatin + Trofinetide Moderate
- Bosentan + Trofinetide Moderate
- Colchicine + Trofinetide Moderate
Frequently asked questions
Can I take Amlodipine-olmesartan with Trofinetide?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trofinetide may inhibit OATP1B1 and OATP1B3 transporters, which could increase olmesartan concentrations. This may amplify hypotension, hyperkalemia or renal effects of olmesartan.
How serious is the interaction between Amlodipine-olmesartan and Trofinetide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, potassium and renal function when the two are combined. Lower the olmesartan dose if exaggerated effects occur.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
