Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Trofinetide
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Trofinetide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trofinetide inhibits OATP1B1 and OATP1B3 and may increase valsartan exposure. This could enhance hypotension or renal effects.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Trofinetide belongs to Central Nervous System.
Why it happens
Inhibition of OATP1B1/1B3 hepatic uptake reduces valsartan clearance.
What to do
Monitor blood pressure and renal function. Reduce the valsartan dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Trofinetide
- Amlodipine-olmesartan-hydrochlorothiazide + Trofinetide Moderate
- Amlodipine-olmesartan + Trofinetide Moderate
- Amlodipine-valsartan + Trofinetide Moderate
- Atorvastatin + Trofinetide Moderate
- Bosentan + Trofinetide Moderate
- Colchicine + Trofinetide Moderate
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Trofinetide?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trofinetide inhibits OATP1B1 and OATP1B3 and may increase valsartan exposure. This could enhance hypotension or renal effects.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Trofinetide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function. Reduce the valsartan dose if hypotension occurs.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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