Drug interactions
Bosentan + Trofinetide
Severity: Moderate
Bosentan and Trofinetide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trofinetide may inhibit OATP1B1 and OATP1B3, which carry bosentan into the liver. This could raise bosentan concentrations and the risk of liver injury, hypotension and edema.
What this interaction means in plain words
Bosentan and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Trofinetide belongs to Central Nervous System.
Why it happens
Trofinetide inhibits OATP1B1/1B3 hepatic uptake of bosentan, reducing its clearance.
What to do
Monitor liver aminotransferases, blood pressure and fluid status more frequently. Consider alternatives to bosentan if abnormalities develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Cyclosporine Contraindicated
- Bosentan + Glyburide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
Other interactions of Trofinetide
Frequently asked questions
Can I take Bosentan with Trofinetide?
MediHelp rates the interaction as moderate. Bosentan and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trofinetide may inhibit OATP1B1 and OATP1B3, which carry bosentan into the liver. This could raise bosentan concentrations and the risk of liver injury, hypotension and edema.
How serious is the interaction between Bosentan and Trofinetide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver aminotransferases, blood pressure and fluid status more frequently. Consider alternatives to bosentan if abnormalities develop.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Cyclosporine, Glyburide. The full list is on the Bosentan page.
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