Drug interactions
Amlodipine-olmesartan + Verapamil
Severity: Moderate
Amlodipine-olmesartan and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil inhibits CYP3A4 and can raise amlodipine exposure, and both are calcium channel blockers that lower blood pressure. Combining them can cause excessive hypotension, peripheral edema and reflex effects, and verapamil adds negative chronotropic and inotropic effects.
What this interaction means in plain words
Amlodipine-olmesartan and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Verapamil belongs to Cardiovascular.
Why it happens
Additive calcium channel blockade plus modest CYP3A4 inhibition by verapamil that increases amlodipine concentrations.
What to do
Monitor blood pressure, heart rate and edema, and reduce the amlodipine dose if hypotension or bradycardia occurs. Avoid dual calcium channel blocker therapy unless clearly required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Verapamil?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil inhibits CYP3A4 and can raise amlodipine exposure, and both are calcium channel blockers that lower blood pressure. Combining them can cause excessive hypotension, peripheral edema and reflex effects, and verapamil adds negative chronotropic and inotropic effects.
How serious is the interaction between Amlodipine-olmesartan and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and edema, and reduce the amlodipine dose if hypotension or bradycardia occurs. Avoid dual calcium channel blocker therapy unless clearly required.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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