Drug interactions
Amlodipine-valsartan + Atorvastatin
Severity: Minor
Amlodipine-valsartan and Atorvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan is an OATP1B1 substrate and atorvastatin also uses this transporter, so mutual effects are possible. Clinically relevant changes have not been established and the combination is widely used.
What this interaction means in plain words
Amlodipine-valsartan and Atorvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-valsartan belongs to Cardiovascular; Atorvastatin belongs to Cardiovascular.
Why it happens
Possible competition at hepatic OATP1B1 uptake, supported mainly by in vitro data.
What to do
No dose adjustment is needed; report unexplained muscle pain and monitor blood pressure as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Frequently asked questions
Can I take Amlodipine-valsartan with Atorvastatin?
MediHelp rates the interaction as minor. Amlodipine-valsartan and Atorvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valsartan is an OATP1B1 substrate and atorvastatin also uses this transporter, so mutual effects are possible. Clinically relevant changes have not been established and the combination is widely used.
How serious is the interaction between Amlodipine-valsartan and Atorvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; report unexplained muscle pain and monitor blood pressure as usual.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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