Drug interactions
Amlodipine-valsartan + Axitinib
Severity: Minor
Amlodipine-valsartan and Axitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Axitinib is metabolized mainly by CYP3A4, and amlodipine is only a weak CYP3A4 inhibitor, so any effect on exposure is likely small. Axitinib itself commonly causes hypertension, so blood pressure control is the practical concern.
What this interaction means in plain words
Amlodipine-valsartan and Axitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-valsartan belongs to Cardiovascular; Axitinib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by amlodipine may slightly raise axitinib exposure.
What to do
No dose change is needed; monitor blood pressure and axitinib adverse effects during therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Amlodipine-valsartan with Axitinib?
MediHelp rates the interaction as minor. Amlodipine-valsartan and Axitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Axitinib is metabolized mainly by CYP3A4, and amlodipine is only a weak CYP3A4 inhibitor, so any effect on exposure is likely small. Axitinib itself commonly causes hypertension, so blood pressure control is the practical concern.
How serious is the interaction between Amlodipine-valsartan and Axitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor blood pressure and axitinib adverse effects during therapy.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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