Drug interactions
Amlodipine-valsartan + Enoxaparin
Severity: Moderate
Amlodipine-valsartan and Enoxaparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enoxaparin can suppress aldosterone secretion and cause hyperkalemia, and the risk rises when combined with an ARB, particularly in renal impairment, diabetes or prolonged use.
What this interaction means in plain words
Amlodipine-valsartan and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Enoxaparin belongs to Cardiovascular.
Why it happens
Heparin-induced suppression of adrenal aldosterone synthesis adds to valsartan's potassium retention.
What to do
Monitor serum potassium and renal function if enoxaparin continues beyond several days or in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Amlodipine-valsartan with Enoxaparin?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enoxaparin can suppress aldosterone secretion and cause hyperkalemia, and the risk rises when combined with an ARB, particularly in renal impairment, diabetes or prolonged use.
How serious is the interaction between Amlodipine-valsartan and Enoxaparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function if enoxaparin continues beyond several days or in high-risk patients.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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