Drug interactions
Amlodipine-valsartan + Fluvastatin
Severity: Minor
Amlodipine-valsartan and Fluvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan has been reported to interact with OATP1B1 in vitro, but fluvastatin is mainly cleared by CYP2C9 and a clinically meaningful rise in statin exposure is not established. The risk of myopathy from this combination is considered low.
What this interaction means in plain words
Amlodipine-valsartan and Fluvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-valsartan belongs to Cardiovascular; Fluvastatin belongs to Cardiovascular.
Why it happens
Possible competition at hepatic OATP1B1 uptake, which is theoretical for this pair.
What to do
No dose change is needed; ask patients to report unexplained muscle pain or weakness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Frequently asked questions
Can I take Amlodipine-valsartan with Fluvastatin?
MediHelp rates the interaction as minor. Amlodipine-valsartan and Fluvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valsartan has been reported to interact with OATP1B1 in vitro, but fluvastatin is mainly cleared by CYP2C9 and a clinically meaningful rise in statin exposure is not established. The risk of myopathy from this combination is considered low.
How serious is the interaction between Amlodipine-valsartan and Fluvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; ask patients to report unexplained muscle pain or weakness.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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