Drug interactions
Amlodipine-valsartan + Istradefylline
Severity: Moderate
Amlodipine-valsartan and Istradefylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At 40 mg daily, istradefylline raises exposure to CYP3A4 substrates, which can increase amlodipine levels. This may cause hypotension, dizziness and edema. This effect was not seen at 20 mg daily.
What this interaction means in plain words
Amlodipine-valsartan and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline at higher doses weakly inhibits CYP3A4, reducing amlodipine metabolism.
What to do
Monitor blood pressure and edema if istradefylline 40 mg daily is used. Consider reducing the amlodipine dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Amlodipine-valsartan with Istradefylline?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At 40 mg daily, istradefylline raises exposure to CYP3A4 substrates, which can increase amlodipine levels. This may cause hypotension, dizziness and edema. This effect was not seen at 20 mg daily.
How serious is the interaction between Amlodipine-valsartan and Istradefylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema if istradefylline 40 mg daily is used. Consider reducing the amlodipine dose if adverse effects appear.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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