Drug interactions
Amlodipine-valsartan + Meloxicam
Severity: Moderate
Amlodipine-valsartan and Meloxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meloxicam can blunt the antihypertensive effect of valsartan and raises the risk of renal impairment and hyperkalemia when combined with an angiotensin receptor blocker. Elderly and volume-depleted patients are most vulnerable.
What this interaction means in plain words
Amlodipine-valsartan and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Meloxicam belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal perfusion and potassium excretion, opposing angiotensin receptor blockade.
What to do
Use the lowest effective meloxicam dose for the shortest time and maintain hydration. Monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Frequently asked questions
Can I take Amlodipine-valsartan with Meloxicam?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meloxicam can blunt the antihypertensive effect of valsartan and raises the risk of renal impairment and hyperkalemia when combined with an angiotensin receptor blocker. Elderly and volume-depleted patients are most vulnerable.
How serious is the interaction between Amlodipine-valsartan and Meloxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective meloxicam dose for the shortest time and maintain hydration. Monitor blood pressure, creatinine and potassium.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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