Drug interactions
Amlodipine-valsartan + Nelfinavir
Severity: Minor
Amlodipine-valsartan and Nelfinavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir may inhibit hepatic OATP1B1 uptake of valsartan and increase its exposure, although the clinical effect is expected to be small. Amlodipine levels may also rise because nelfinavir inhibits CYP3A4.
What this interaction means in plain words
Amlodipine-valsartan and Nelfinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-valsartan belongs to Cardiovascular; Nelfinavir belongs to Anti Virals.
Why it happens
Inhibition of OATP1B1-mediated hepatic uptake of valsartan and of CYP3A4 metabolism of amlodipine.
What to do
Monitor blood pressure and for edema when starting nelfinavir. Reduce the antihypertensive dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Amlodipine-valsartan with Nelfinavir?
MediHelp rates the interaction as minor. Amlodipine-valsartan and Nelfinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nelfinavir may inhibit hepatic OATP1B1 uptake of valsartan and increase its exposure, although the clinical effect is expected to be small. Amlodipine levels may also rise because nelfinavir inhibits CYP3A4.
How serious is the interaction between Amlodipine-valsartan and Nelfinavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for edema when starting nelfinavir. Reduce the antihypertensive dose if hypotension occurs.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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