Drug interactions
Amlodipine-valsartan + Nilotinib
Severity: Moderate
Amlodipine-valsartan and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib is a moderate CYP3A4 inhibitor and may raise amlodipine concentrations, causing more hypotension and peripheral edema. Nilotinib also prolongs the QT interval, which is separate from this interaction but relevant to the overall cardiovascular risk of the patient.
What this interaction means in plain words
Amlodipine-valsartan and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Nilotinib belongs to Oncology.
Why it happens
Nilotinib inhibits CYP3A4-mediated metabolism of amlodipine, increasing its exposure.
What to do
Monitor blood pressure and edema after nilotinib is started and reduce the amlodipine dose if hypotension occurs. Check ECG and electrolytes per nilotinib labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Amlodipine-valsartan with Nilotinib?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib is a moderate CYP3A4 inhibitor and may raise amlodipine concentrations, causing more hypotension and peripheral edema. Nilotinib also prolongs the QT interval, which is separate from this interaction but relevant to the overall cardiovascular risk of the patient.
How serious is the interaction between Amlodipine-valsartan and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema after nilotinib is started and reduce the amlodipine dose if hypotension occurs. Check ECG and electrolytes per nilotinib labeling.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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