Drug interactions
Amlodipine-valsartan + Pazopanib
Severity: Minor
Amlodipine-valsartan and Pazopanib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib inhibits OATP1B1 in vitro and could modestly raise valsartan concentrations. Pazopanib itself commonly causes hypertension, which complicates blood pressure assessment.
What this interaction means in plain words
Amlodipine-valsartan and Pazopanib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-valsartan belongs to Cardiovascular; Pazopanib belongs to Oncology.
Why it happens
Possible inhibition of OATP1B1-mediated hepatic uptake of valsartan; this is predicted from in vitro data.
What to do
No empirical dose adjustment is needed. Monitor blood pressure regularly during pazopanib therapy and titrate antihypertensives to response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Amlodipine-valsartan with Pazopanib?
MediHelp rates the interaction as minor. Amlodipine-valsartan and Pazopanib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pazopanib inhibits OATP1B1 in vitro and could modestly raise valsartan concentrations. Pazopanib itself commonly causes hypertension, which complicates blood pressure assessment.
How serious is the interaction between Amlodipine-valsartan and Pazopanib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose adjustment is needed. Monitor blood pressure regularly during pazopanib therapy and titrate antihypertensives to response.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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