Drug interactions
Amlodipine-valsartan + Propranolol
Severity: Moderate
Amlodipine-valsartan and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol adds to the blood pressure lowering of amlodipine and valsartan, which is often intended but can cause excessive hypotension and bradycardia. Beta-blockers can also mask hypoglycemia symptoms and slightly raise potassium, and valsartan is harmful in pregnancy.
What this interaction means in plain words
Amlodipine-valsartan and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Propranolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects through beta-blockade, vasodilation and renin-angiotensin blockade.
What to do
Monitor blood pressure, heart rate and potassium when starting or adjusting therapy. Titrate doses gradually and avoid abrupt propranolol withdrawal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Amlodipine-valsartan with Propranolol?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propranolol adds to the blood pressure lowering of amlodipine and valsartan, which is often intended but can cause excessive hypotension and bradycardia. Beta-blockers can also mask hypoglycemia symptoms and slightly raise potassium, and valsartan is harmful in pregnancy.
How serious is the interaction between Amlodipine-valsartan and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and potassium when starting or adjusting therapy. Titrate doses gradually and avoid abrupt propranolol withdrawal.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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