Drug interactions
Amlodipine-valsartan + Timolol
Severity: Moderate
Amlodipine-valsartan and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Timolol, a beta-blocker, adds to the blood pressure lowering of amlodipine and valsartan, which can cause excessive hypotension, bradycardia or fatigue. Even ophthalmic timolol is absorbed systemically and can produce beta-blocker effects. The combination is often used on purpose in hypertension but needs monitoring.
What this interaction means in plain words
Amlodipine-valsartan and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-valsartan belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic antihypertensive effects through beta-blockade, calcium channel blockade and angiotensin receptor blockade.
What to do
Monitor blood pressure and heart rate, especially when starting or adjusting doses. Reduce the dose of one agent if symptomatic hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Frequently asked questions
Can I take Amlodipine-valsartan with Timolol?
MediHelp rates the interaction as moderate. Amlodipine-valsartan and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Timolol, a beta-blocker, adds to the blood pressure lowering of amlodipine and valsartan, which can cause excessive hypotension, bradycardia or fatigue. Even ophthalmic timolol is absorbed systemically and can produce beta-blocker effects. The combination is often used on purpose in hypertension but needs monitoring.
How serious is the interaction between Amlodipine-valsartan and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, especially when starting or adjusting doses. Reduce the dose of one agent if symptomatic hypotension or bradycardia occurs.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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