Drug interactions
Amlodipine-valsartan + Tolvaptan
Severity: Minor
Amlodipine-valsartan and Tolvaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolvaptan is an aquaretic that does not itself raise potassium, and labeling notes a possible rise in serum potassium with potassium-sparing agents and ARBs. The effect is modest and the clinical significance is limited; rapid fluid loss and volume depletion could add to hypotension.
What this interaction means in plain words
Amlodipine-valsartan and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-valsartan belongs to Cardiovascular; Tolvaptan belongs to Endocrine.
Why it happens
Tolvaptan's V2 antagonism causes free water loss and hemoconcentration, which may modestly raise potassium alongside angiotensin receptor blockade.
What to do
Check serum potassium and sodium during tolvaptan initiation, and watch for hypotension from volume loss.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-valsartan
- Aliskiren + Amlodipine-valsartan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Aldesleukin + Amlodipine-valsartan Major
- Amifostine + Amlodipine-valsartan Major
- Amiloride + Amlodipine-valsartan Major
- Amlodipine-valsartan + Benazepril Major
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Amlodipine-valsartan with Tolvaptan?
MediHelp rates the interaction as minor. Amlodipine-valsartan and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tolvaptan is an aquaretic that does not itself raise potassium, and labeling notes a possible rise in serum potassium with potassium-sparing agents and ARBs. The effect is modest and the clinical significance is limited; rapid fluid loss and volume depletion could add to hypotension.
How serious is the interaction between Amlodipine-valsartan and Tolvaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and sodium during tolvaptan initiation, and watch for hypotension from volume loss.
What other medicines interact with Amlodipine-valsartan?
MediHelp also lists interactions of Amlodipine-valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Amlodipine-valsartan page.
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