Drug interactions
Amoxapine + Aripiprazole
Severity: Moderate
Amoxapine and Aripiprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine has dopamine-blocking activity through its metabolite, and combining it with aripiprazole increases the risk of extrapyramidal symptoms, tardive dyskinesia and neuroleptic malignant syndrome. Sedation and QT effects may also be additive. Amoxapine may also inhibit CYP2D6 modestly, raising aripiprazole exposure.
What this interaction means in plain words
Amoxapine and Aripiprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive dopamine D2 receptor antagonism, CNS depression and QT effects, with possible CYP2D6-mediated increase in aripiprazole levels.
What to do
Monitor for extrapyramidal symptoms, sedation, hyperthermia and rigidity, and obtain an ECG if other QT-prolonging risks exist. Use the lowest effective doses of both drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Amoxapine with Aripiprazole?
MediHelp rates the interaction as moderate. Amoxapine and Aripiprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine has dopamine-blocking activity through its metabolite, and combining it with aripiprazole increases the risk of extrapyramidal symptoms, tardive dyskinesia and neuroleptic malignant syndrome. Sedation and QT effects may also be additive. Amoxapine may also inhibit CYP2D6 modestly, raising aripiprazole exposure.
How serious is the interaction between Amoxapine and Aripiprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, sedation, hyperthermia and rigidity, and obtain an ECG if other QT-prolonging risks exist. Use the lowest effective doses of both drugs.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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