Drug interactions
Amoxapine + Brompheniramine
Severity: Moderate
Amoxapine and Brompheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine is a sedating antidepressant with anticholinergic activity, and brompheniramine adds to both sedation and anticholinergic burden. This can cause drowsiness, dry mouth, constipation, urinary retention and confusion, especially in older patients.
What this interaction means in plain words
Amoxapine and Brompheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and anticholinergic effects.
What to do
Monitor for oversedation and anticholinergic effects, and prefer a non-sedating antihistamine if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Frequently asked questions
Can I take Amoxapine with Brompheniramine?
MediHelp rates the interaction as moderate. Amoxapine and Brompheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine is a sedating antidepressant with anticholinergic activity, and brompheniramine adds to both sedation and anticholinergic burden. This can cause drowsiness, dry mouth, constipation, urinary retention and confusion, especially in older patients.
How serious is the interaction between Amoxapine and Brompheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and anticholinergic effects, and prefer a non-sedating antihistamine if possible.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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