Drug interactions
Belladonna and opium + Brompheniramine
Severity: Major
Belladonna and opium and Brompheniramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opium causes sedation and respiratory depression, and belladonna adds anticholinergic effects. Brompheniramine adds both sedative and anticholinergic burden, raising the risks of oversedation, constipation, urinary retention and confusion.
What this interaction means in plain words
Belladonna and opium and Brompheniramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from opioid agonism and H1 antagonism, plus additive anticholinergic effects.
What to do
Use the lowest effective doses and monitor sedation, respiratory rate and bowel and bladder function. Avoid in patients at risk of respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Brompheniramine
Frequently asked questions
Can I take Belladonna and opium with Brompheniramine?
MediHelp rates the interaction as major. Belladonna and opium and Brompheniramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opium causes sedation and respiratory depression, and belladonna adds anticholinergic effects. Brompheniramine adds both sedative and anticholinergic burden, raising the risks of oversedation, constipation, urinary retention and confusion.
How serious is the interaction between Belladonna and opium and Brompheniramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation, respiratory rate and bowel and bladder function. Avoid in patients at risk of respiratory depression.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Calcium / magnesium / potassium / sodium oxybates. The full list is on the Brompheniramine page.
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