Drug interactions
Benzhydrocodone / acetaminophen + Brompheniramine
Severity: Major
Benzhydrocodone / acetaminophen and Brompheniramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzhydrocodone is an opioid prodrug of hydrocodone, and brompheniramine can add to sedation and respiratory depression. Opioid labeling warns about combining with other CNS depressants.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Brompheniramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from opioid agonism and H1 antagonism.
What to do
Use the lowest effective doses and monitor sedation and respiratory rate. Prefer a non-sedating antihistamine where possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Brompheniramine
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Brompheniramine?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Brompheniramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benzhydrocodone is an opioid prodrug of hydrocodone, and brompheniramine can add to sedation and respiratory depression. Opioid labeling warns about combining with other CNS depressants.
How serious is the interaction between Benzhydrocodone / acetaminophen and Brompheniramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and respiratory rate. Prefer a non-sedating antihistamine where possible.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Calcium / magnesium / potassium / sodium oxybates. The full list is on the Brompheniramine page.
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