Drug interactions
Amoxapine + Budesonide-formoterol
Severity: Major
Amoxapine and Budesonide-formoterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants like amoxapine can potentiate the cardiovascular effects of formoterol, causing tachycardia and arrhythmia. Both can also prolong the QT interval.
What this interaction means in plain words
Amoxapine and Budesonide-formoterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Tricyclic inhibition of norepinephrine reuptake and additive QT prolongation potentiate beta-agonist cardiac effects.
What to do
Use with close ECG, heart rate and blood pressure monitoring, or choose an alternative antidepressant. Check potassium in patients with other risk factors.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Budesonide-formoterol
Frequently asked questions
Can I take Amoxapine with Budesonide-formoterol?
MediHelp rates the interaction as major. Amoxapine and Budesonide-formoterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclic antidepressants like amoxapine can potentiate the cardiovascular effects of formoterol, causing tachycardia and arrhythmia. Both can also prolong the QT interval.
How serious is the interaction between Amoxapine and Budesonide-formoterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use with close ECG, heart rate and blood pressure monitoring, or choose an alternative antidepressant. Check potassium in patients with other risk factors.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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