Drug interactions
Arsenic trioxide + Budesonide-formoterol
Severity: Major
Arsenic trioxide and Budesonide-formoterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Arsenic trioxide markedly prolongs QT and can cause torsades de pointes. Formoterol can add to QT effects and lower potassium, increasing arrhythmia risk.
What this interaction means in plain words
Arsenic trioxide and Budesonide-formoterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Arsenic trioxide belongs to Oncology; Budesonide-formoterol belongs to Respiratory.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia.
What to do
Avoid when possible; if needed, monitor ECG and keep potassium and magnesium within normal range. Use a non-beta-agonist alternative where feasible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Budesonide-formoterol
Other interactions of Arsenic trioxide
- Amiodarone + Arsenic trioxide Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Arsenic trioxide + Clomipramine Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Arsenic trioxide + Fluphenazine Contraindicated
- Arsenic trioxide + Gemifloxacin Contraindicated
Frequently asked questions
Can I take Arsenic trioxide with Budesonide-formoterol?
MediHelp rates the interaction as major. Arsenic trioxide and Budesonide-formoterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Arsenic trioxide markedly prolongs QT and can cause torsades de pointes. Formoterol can add to QT effects and lower potassium, increasing arrhythmia risk.
How serious is the interaction between Arsenic trioxide and Budesonide-formoterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid when possible; if needed, monitor ECG and keep potassium and magnesium within normal range. Use a non-beta-agonist alternative where feasible.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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