Drug interactions
Amoxapine + Cariprazine
Severity: Moderate
Amoxapine and Cariprazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine is a sedating antidepressant with dopamine-blocking activity, so combining it with cariprazine can increase sedation, extrapyramidal symptoms, and the risk of tardive dyskinesia and neuroleptic malignant syndrome. Additive anticholinergic and cardiac effects are also possible.
What this interaction means in plain words
Amoxapine and Cariprazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and dopamine D2 antagonism.
What to do
Monitor for sedation, extrapyramidal symptoms and akathisia, and use the lowest effective doses. Consider an antidepressant without D2 blockade if movement symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Frequently asked questions
Can I take Amoxapine with Cariprazine?
MediHelp rates the interaction as moderate. Amoxapine and Cariprazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine is a sedating antidepressant with dopamine-blocking activity, so combining it with cariprazine can increase sedation, extrapyramidal symptoms, and the risk of tardive dyskinesia and neuroleptic malignant syndrome. Additive anticholinergic and cardiac effects are also possible.
How serious is the interaction between Amoxapine and Cariprazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, extrapyramidal symptoms and akathisia, and use the lowest effective doses. Consider an antidepressant without D2 blockade if movement symptoms develop.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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