Drug interactions
Amoxapine + Chlorzoxazone
Severity: Moderate
Amoxapine and Chlorzoxazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amoxapine is a sedating tricyclic-type antidepressant and with chlorzoxazone may cause increased drowsiness, dizziness and impaired coordination.
What this interaction means in plain words
Amoxapine and Chlorzoxazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression.
What to do
Monitor for oversedation, especially in older adults, and use the lowest effective doses. Counsel patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Frequently asked questions
Can I take Amoxapine with Chlorzoxazone?
MediHelp rates the interaction as moderate. Amoxapine and Chlorzoxazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine is a sedating tricyclic-type antidepressant and with chlorzoxazone may cause increased drowsiness, dizziness and impaired coordination.
How serious is the interaction between Amoxapine and Chlorzoxazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, especially in older adults, and use the lowest effective doses. Counsel patients to avoid driving and alcohol.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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